SIGNIFICANCE OF RAISED SERUM URIC ACID LEVELS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Background: Hyperuricemia is common in chronic kidney disease (CKD). The present study evaluated the associations between baseline serum uric acid levels with mortality and end-stage renal disease (ESRD). Chronic kidney disease (CKD) is a serious condition associated with premature mortality, decreased quality of life, and increased health - care expenditures. Chronic kidney disease occurs when one suffers from gradual and usually permanent loss of kidney function over time. Material and Method: This is a prospective observational study conducted in Nephrology Dept affliated to Biochemistry Dept, Govt.General Hospital,Kurnool From June 2018 to may 2019. In this study, 158 CKD patients were studied with detailed clinical and laboratory examination and divided into two groups: one group included 60 CKD patients with raised serum uric acid and another group containing 98 CKD patients with normal serum uric acid. Both groups were age matched. Results: In our study, prevalence of raised serum uric acid in CKD patients was found to be 38.4%. It is observed that, CKD patients with raised serum uric acid were predominantly male and presented mainly in later part of life. There is statistically significant (p<0.05) positive correlation is found between serum uric acid and stages and severity of CKD, hypertension, diabetes mellitus, serum BUN, serum creatinine, urine albuminuria, anaemia, cardiovascular disease, mortality and negative correlation with eGFR . Conclusion: In CKD patients, higher serum uric acid levels were associated with higher degree of renal dysfunction, hypertension, diabetes, urine albuminuria, anaemia, cardiovascular disease and mortality. It is found that most common cause of mortality in CKD patients with raised serum uric acid was cardiovascular disease/events.