ANTI-PARKINSONIAN EFFECT OF TRIGONELLA FOENUM-GRAECUM IN DRUG INDUCED CATALEPSY IN MOUSE MODEL

Trigonella foenum-graecum L. (Leguminoseae) is an ancient and annual legume crop mainly grown for multiple uses in many parts of the world like Asia, Europe, Africa and Australia. It possesses anticarcinogenic activities, hypocholesterolemic activities, hypoglycemic activities, antioxidant, antineoplastic agent, In the present anticataleptic activity of whole plant Trigonella foenum-graecum in Haloperidol induced and clonidine induced catalepsy in mice. Methanolic extract of whole plant Trigonella foenum-graecum was prepared and evaluated for anti-cataleptic property. The mice were divided into 5 groups (n=6). Group I is served as control. Group II [(haloperidol 1.0 mg/kg body weight., i.p. in Haloperidol induced catalepsy (HIC)]. Group III (test extract, 200 mg/kg body weight, p.o.). Group IV (test extract, 400 mg/kg body weight respectively.p.o.), Group V (levodopa and carbidopa (100mg + 25 mg/kg, i.p.). The anti-cataleptic effect of Trigonella foenum-graecum, was evaluated by locomotor activity and rota rod test using mice models. Histopathological studies of brain in mice were examined. Trigonella foenum-graecum extract (200 and 400 mg/kg body weight, p.o.) was found to decrease the duration of catalepsy significantly (P < 0.01) in standard bar test as compared to haloperidol group. Comparatively, METFG (400 mg/kg body weight, p.o.) was more potent anti-cataleptic activity than METFG (200 mg/kg body weight, p.o.)