COMPARATIVE MICROANATOMY OF ORGANS OF ANENCEPHALIC & NORMAL FETUSES OF DIFFERENT GESTATIONAL AGE GROUPS

Background: Anencephaly is Neural tube defect which is a most common birth defects. This was a hospital based case finding study that covered 60 patients with anencephaly & their respective mothers conducted in hospitals in Bangalore Medical College & Research Institute from 2014 to 2017. Methods: The study includes 60 anencephalic fetuses (23 males & 37 females) of 20-30 weeks. The fetuses were examined for external abnormalities & dissected. Dissected fetal kidney, ureter, stomach, suprarenal gland, thyroid gland, pancreas, lung and liver tissues were processed & stained with H&E. Results: Histological study of the anencephalic organs were studied, Stomach was normal in all the cases. Ureter in 98% cases was normal & in 2% cases, illformed muscular layer was seen. Only in 2.2% of cases Suprarenal gland showed rosettes cell tumor which are little rounded grouping of cells found in tumors .Abnormal development of some hepatocytes & hepatic sinusoids was induced by abnormal development of nervous system of anencephalic fetus which was also found.