Formulation and Evaluation of Cefixime Trihydrate Dispersible Tablets

Therapeutically active ingredients like tablet and capsule are conventional pharmaceutical dosage forms for manufacture, storage and ensure dosage uniformity. However, this dosage forms like capsules and tablets, often present ingestion problems such as difficulty in swallowing for the debilitated patients, particularly for paediatric and geriatric populations. This may result in a high incidence of non compliance and ineffective therapy, which may prove to be fatal in case of serious conditions. Suspension dosage forms could solve this problem, but they have other associated drawbacks like lower physical and chemical stability and high cost of manufacturing. Suspensions are also inconvenient to carry while travelling and also involve the risk of inaccurate measurement and dosing. Thus, there is a need for oral pharmaceutical composition, which can be taken orally without the need of swallowing it and act as a viable substitute for suspensions. Accordingly, provided are water dispersible tablet compositions, which can either be chewed or can be readily dispersed in water before oral administration. One of the key requirements of water dispersible tablet is they could dissolve in an aqueous medium within a short time period for example, less than three minutes, to form a smooth suspension without any coarse lumps. Dispersible tablets provide advantages of both tablets and liquid formulations. These are convenient to carry, easy to manufacture and more stable dosage forms. Ms. Remya S. B | Dr. Subash Chandran M. P | Ms. Aparna P "Formulation and Evaluation of Cefixime Trihydrate Dispersible Tablets" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29627.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/29627/formulation-and-evaluation-of-cefixime-trihydrate-dispersible-tablets/ms-remya-s-b