FEATURES OF INTOXICATION SYNDROME IN PATIENTS WITH NONSPECIFIC SPINAL OSTEOMYELITIS

Background. Nonspecific spinal osteomyelitis (NSO) is a serious purulent-inflammatory disease, accompanied by high mortality and disability of patients. Aim. To study the characteristics of intoxication syndrome (IS) in patients with NSO and to assess the degree of influence of the activity of the inflammatory process in the bone structures of the spinal column on the degree of intoxication. Material and methods. The neutrophil-lymphocyte ratio, leukocyte and hematological indices of intoxication, nuclear index of the degree of endotoxicosis, immunoreactivity index were studied in 46 patients with NSO. The relationship between the activity of the inflammatory process in the structures of the spinal column and the degree of IS has been studied. Results. The severity of IS in patients with complicated forms of NSO was significantly (p <0,05) higher than in patients with uncomplicated forms. The correlation between the degree of accumulation of radiopharmaceuticals in the structures of the spine and the severity of IS was not established (p> 0,05). A mathematical model was developed (Рχ2 = 0,0003), which makes it possible to suspect purulent complications in a patient with NSO by the severity of IS (sensitivity 65,38%, specificity 80%). Conclusion. The presence of IS makes it possible to suspect purulent complications in patients with NSO, which requires an extended diagnostic preoperative search.