SYNTHESIS OF DERIVATIVES OF 1,4,8,11-TETRAAZACYCLOTETRADECANE

Journal: International Journal of Civil Engineering and Technology (IJCIET) (Vol.10, No. 10)

Publication Date: 2019-09-24

Authors : Khadija Nabih; Abdesselam Baouid Hanri Handel Mohamed Yazidi Mohamed Maatallah Mohamed Adardour;

Page : 462-469

Keywords : radiopharmaceutical; tetraazamacrocycles; mono-N-functionalization; bis-functionalization;

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Abstract

Our interest is to develop new synthesis strategies and to develop bi-functional tetraazamacrocyclic compounds for nuclear medicine applications in radiopharmaceuticals. We have carried out a functionalization assessment of 1,4,8,8,11-tetraazacyclotetradecane. First, we evaluated the potential of the aminal tool for mono-N-functionalization and then bis-functionalization of 1,4,8,11- tetraazacyclotetradecane

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SYNTHESIS OF DERIVATIVES OF 1,4,8,11-TETRAAZACYCLOTETRADECANE

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