Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion
Journal: Journal of Pharmacy & Pharmacognosy Research (Vol.8, No. 2)Publication Date: 2020-03-20
Authors : Febriyenti; Indra Peki; Zaini Erizal; Ismed Friardi; Lucida Henny;
Page : 127-134
Keywords : dissolution profile; polyvinylpyrrolidone; quercetin; solid dispersion; solubility;
Abstract
Context: The use of quercetin as a potential active pharmaceutical ingredient is limited by low aqueous solubility leading to low bioavailability. A spray-dried solid dispersion technique is used to increase the solubility and dissolution profiles of quercetin. Aims: To prepare and characterize quercetin solid dispersion using polyvinylpyrrolidone (PVP) K-30. Methods: Solid dispersions (SDs) were prepared by spray drying technique at quercetin/PVP K-30 ratios of 10/90, 20/80, 30/70, 40/60 and 50/50. A physical mixture of quercetin/PVP K-30 (50/50) and pure quercetin were used as comparisons. The SDs were characterized by powder X-Ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform IR (FTIR) spectroscopy, solubility and dissolution studies. The effect of the drug/polymer ratio on the solubility of quercetin was also studied. Results: Quercetin SDs appeared as amorphous form as confirmed by XRD. Quercetin was better dispersed as the drug/polymer ratio decreased. SD with ratio 10/90 showed regular spherical particles in the size range of 0-35 µm. The solubility of quercetin increased with decreasing drug/polymer ratio. Preparation of SDs influence the solubility significantly (p<0.01). The increase in solubility is probably due to a hydrogen bond between quercetin and PVP K30 as confirmed by FTIR spectra. SD with ratio 10/90 showed a high dissolution rate (95.12 ± 1.83%) within 120 min in comparison to pure quercetin (19.37 ± 0.58%) or physical mixture (37.85 ± 0.85%). Conclusions: Preparation of quercetin SDs with PVP K30 by spray drying technique results in amorphous spherical particles. There was an increase in solubility and percent dissolved with a decrease in drug/polymer ratio.
Other Latest Articles
- Equilibrium solubility using shake-flask method of JM-20: a synthetic molecule with neuroprotective action
- Acute toxicity of ethanolic extract of Lansium domesticum cv kokossan leaves in female Wistar rats
- Ex-vivo inhibition of uterine contractility by the stem bark extracts of Omphalocarpum procerum P.Beauv. (Sapotaceae) in mouse models
- Caspase mediated cytotoxicity of a yellow pigment produced by Exiguobacterium alkaliphilum on human cancer cell lines
- Pharmacognostic study and evaluation of the antioxidant capacity of the fruit of two varieties of Nephelium lappaceum L. (Sapindaceae), (rambutan)
Last modified: 2020-01-19 16:10:51