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From Lab to Pharmacy Shelves: The Story of a Plant Derived Anticancer Drug, "Paclitaxel"

Journal: Journal of Bioresource Management (JBM) (Vol.2, No. 4)

Publication Date:

Authors : ;

Page : 28-39

Keywords : secondary metabolites; Taxus brevifolia; taxol; Paclitaxel.;

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Abstract

Paclitaxel (Taxol®) is a highly praised anticancer drug, known for its efficiency in treating different cancers. It belongs to a class of compounds called taxanes that are derived from the plants of the genus Taxus. This drug is now FDA approved, but there was a time when the name Taxol was less known to the scientific world. Taxol, being a unique molecule in its structure, properties and mechanism of action, has undergone more than 30 years of trials, and faced a lot of hurdles to leave the bench of a laboratory and reach the shelves of a pharmacy. This review focuses on the story of Taxol, how it began and how it achieved the status of Paclitaxel.

Last modified: 2020-01-20 23:40:39