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More on choice of places for insertion of tested samples of polymer implants in study of reaction of tissues of macroorganism

Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.27, No. 4)

Publication Date:

Authors : ;

Page : 503-511

Keywords : implant; biological compatibility; implantation; capsule; operation; tissue reaction; preclinical trial.;

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Aim. Assessment of different methods of implantation and autopsy of portions of tissue at the sites of insertion of polymer implants. Materials and Methods. Samples of new vessel prostheses (OOO Lintex, Saint Petersburg) were implanted into the subcutaneous layer of the abdominal wall and paravertebral area of 30 rats. Morphological changes at the sites of insertion of implants, and also variation of the values of criteria developed by the authors were evaluated. The results obtained in studies, were evaluated by experts on the basis of the evidence of artefacts in microphotographs, of expected probability for damage to the implant bed in the experiment and in autopsy, of expected technical complexity of getting a sample of the implant and of the periprosthetic capsule in autopsy. Results. The total score of evaluated tissue reactions reached the highest meanings (59) in the group of laboratory animals where the tested samples were implanted into the subcutaneous tissue of the back, which determines this method as least preferable. Variability and error of the method of subcutaneous implantation was higher in the group with implantation of samples into the paravertebral area, since the values of standard deviation (m) in histological examination of this group (from 0.89 to 3.64) exceeded deviations in animals with implantation of the tested prosthetic implants into the abdominal wall (from 0.25 to 2.54). Conclusion. Implantation in the area of the abdominal wall is characterized by lower variability of standard deviation (m) of the morphometric parameters, by lower number of artefacts and by almost complete absence of technical complications in autopsy of the studied material, which, in the opinion of the authors, gives preference to this method in experimental research.

Last modified: 2020-01-21 18:03:22