FUNCTIONAL STATE OF THE CARDIOVASCULAR SYSTEM WITH RESPECT TO THE еNOS T786C GENE POLYMORPHISM

Background. The relationship between the T786C polymorphism of the eNOS gene and functional state of the body is not well understood. Objective. To establish the associations between the T786C polymorphism and the functional state of the organism. Material and methods. The study participants were healthy male volunteers (n = 117). A polymorphic variant of the eNOS gene was determined at the T786C locus. The physical and functional state of the body was evaluated. The results were processed using generally accepted statistical methods. Results. In individuals with the TT genotype diastolic pressure was 4.2% and 5.2% lower compared to the TC and CC genotypes, respectively. The mean dynamic pressure with the TT genotype was 2.7% and 3.1% less than with the TC and CC genotypes. Peripheral vascular resistance in individuals with a dominant genotype was 14.7% lower than in those with a recessive one. The values of the Cerdo index and cardiac index in individuals with C allele were statistically significantly lower compared with the subjects with the TT genotype. Conclusion. The association between the T786C polymorphism and the functional state of the organism was revealed. It seems appropriate to study the formation of oxygen-dependent processes taking into account the above polymorphism.