DETERMINATION OF MATHEMATICAL RELATION BETWEEN QUALITATIVE AND QUANTITATIVE INDICES IN THE CONDUCTED LONGEVITY RESEARCH

Nowadays, the problem of complex action of environmental factors on living organisms is in the focus of modern medical genetics research. Different kinds of organisms have roughly the same set of reactions to the effects of mutagens. The increasing of mutagenic load to the level capable to double the frequency of mutations in a human being can lead to significant changes in the body system. This is especially true for old people, since aging enlarges the intensity of the mutation process through degradation of reparative systems, increasing sensitivity to the action of negative factors, resulting in a more rapid decreasing of vitality. Aging inheres most of all living organisms and takes all levels of living being organization: from mo-lecular to organismal genetics. According to the modern concepts of cell theory of aging, the most important fac-tors are the accumulation of cellular disorders, weakening mechanisms of surviving and cell and tissues' recovering. The most common among them there are spontaneous mutations in somatic cells, including structural aberra-tions of chromosomes. In multivariate aging the latter play significant role. Studying various cytogenetic and molecular genetic disorders in most cases the frequency of their occurrence increasing with age was found. Chromosomal aberrations, micronuclei, the losing of telomeric repeats, mutations in glycophorin locus, DNA's breakings, and so on. The above-mentioned research confirms the important role of genetic factors in the de-velopment of such a multifactorial trait, as life expectan-cy. In order to study the relationship between exogenous and endogenous factors for life expectancy, a comprehensive study of 486 long-living people and 297 individuals of control group was conducted in Ivano-Frankivsk region. After the preliminary complex study (epidemiological, general clinical, clinical-genealogical, cytogenetic, morphodensitometric, electron-microscopic, molecular-genetic, biochemical methods), the obtained results were compared in the two studied groups by correlation and multifactorial analysis. We used the Odds Ratio (OR) mathematical odds ratio method and Pearson's paired correlation method using Statistica. According to the results of the comparative analysis of the significance of the difference in the data in the comparison groups, those that differ significantly are selected for further correlation-regression factor analysis. By gradually removing the irrelevant relationships, two mathematical models were obtained. Found, that the biggest chance to reach longevity have people, that lived in favorable environmental conditions or people, that have high level of xenobiotics detoxification enzymes. Reliable significance on formation livelong and active life had compliance of naturally biorhythms, restrict diet, physical activity, absence of professional hazard and bad habits.In this way the relationships between some cytogenetic indicators of long-livers in the Precarpathian region were established, which made it possible to form two mathematical models of equations of multiple regression (the range of variability of the nuclei of the mucous membrane of the oral cavity, the minimum optical density, micronuclei of the oral mucosa epitheocytes, morphologically altered neutrophil nuclei and oxidative modifications of proteins).