Synthesis and Evaluation of some Substituted Aryl Oxadiazole and Mercapto Oxadiazole Derivatives for Antifungal, Antimicrobial and Antitubercular Activities

A number of substituted aryloxadiazoles and mercaptooxadiazoles are known for their biological importance like anti-bacterial, antifungal, anticancer and anti-inflammatory activity. The present investigation is carried out for the synthesis of certain substituted aryloxadiazole and mercaptooxadiazoles and evaluation of their biological activity. The title compounds have been synthesized by reacting isoniazid with substituted aryl aldehydes to give Schiffs bases which on treatment with aromatic acids in presence of phosphorus oxychloride gives aryl oxadiazoles. Mercaptooxadiazoles were synthesized using isoniazid and carbon disulphide. The newly synthesized compounds have been characterized by IR, 1H NMR and CHN analysis. Selected compounds are screened for antimicrobial and antitubercular activity in vitro. Few of them exhibited promising activity.