COMPATIBILITY STUDIES OF ACETAZOLAMIDE WITH EXCIPIENTS BY USING HIGHPERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TECHNIQUE
Journal: Indian Drugs (Vol.49, No. 5)Publication Date: 2012-05-28
Authors : Murthy T. E. G. K. Bala Vishnu Priya M.; Suresh Babu V. V.;
Page : 39-46
Keywords : ;
Abstract
Compatibility studies are essential for preformulation studies of formulation development. Acetazolamideis a carbonic anhydrase inhibitor used in the treatment and management of cardiac oedema, glaucomaand other conditions. The objective of this study was to evaluate the physical and chemical stability ofacetazolamide, when mixed with excipients as binary mixture. These samples were stored and evaluatedfor related substances at 400/75 % RH for 28 days and 550 for 14 days and the samples were analyzedusing HPLC. The results demonstrated the suitability of acetazolamide with Avicel PH 101, MethocelK4M premium CR hydroxy propyl methyl cellulose, Methocel E10M premium CR hydroxy propyl methylcellulose, talc, sodium lauryl sulphate and size 00 white/white hard gelatin capsule.
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