STUDY OF SOME CARDIAC BIOMARKERS AND OXIDATIVE STRESS MARKERS IN PATIENTS WITH ACUTE CORONARY SYNDROMES

Background: Acute Coronary Syndromes (ACS) represents a pathological, diagnostic, and risk continuum from unstable angina through myocardial infarction (MI) with or without ST-segment elevation. These three conditions share a very similar pathology, although treatment differs. Elevated markers of inflammation, in particular CRP, are associated with an increased risk of future cardiovascular events in healthy subjects, Increased oxidative stress and the generation of the free oxygen radicals can result in modification of LDL to oxidized LDL that could lead to atherosclerotic lesions, Elevated levels of CK-MB have been regarded as biochemical markers of myocyte necrosis. Objective: The aim of this study was to investigate the predictive value of CK-MB and oxidative stress (MDA) in acute coronary syndromes. Patients and Methods: 101 cardiac patients were admitted to the coronary care unit, Ibn alnafees Hospital and Al kindy Hospital over the period July 2013 and March 2014 with the clinical diagnosis of acute coronary syndrome their ages range was (24-84) years, the number of male was (65) (64.36%) and female was (37) (36.63%).39 healthy control (age,sex,matched) were enrolled in this study. All cardiac patients have routine ECG,cardiac biomarkers measurements especially(CK-MB),serelogical markers (C-RP),lipid profile test and oxidative stress markers(MDA).10 ml of blood needed for assessment of the above makers. Results: Oxidative Stress and Cardiac Biomarkers in Patients with Acute Coronary Syndromes (ACS) 101 were found significantly high in patients with ACS as compared to healthy subjects but significantly decreased in HDL-cholesterol in ACS patients as compared to healthy controls. ACS is associated with greater than normal lipid peroxidation. Conclusion: Our study shows a significantly increase in lipid peroxidation and cardiac biomarkers in the circulation of patients with ACS. A significant decrease level of HDL-C were observes only in ACS patients. These finding suggest these biomarkers may be useful diagnosis of patients with ACS.