Visible Spectrophotometric Analysis of Almotriptan Malate In Bulk And FormulationsJournal: International Journal of Scientific & Technology Research (Vol.1, No. 5)
Publication Date: 2012-06-25
Authors : U. Viplava Prasad; M. Syam Bab; B. Kalyana Ramu;
Page : 86-91
Keywords : Almotriptan; Analysis; ACD; Beers Law; HA; SNP; Tablets;
Two simple and sensitive visible spectrophotometric methods are described for the determination of almotriptan malate in bulk and pharmaceutical preparations based on the formation of colored molecular complex with sodium nitroprusside in presence of hydroxyl amine under alkaline conditions M1 or SNP-acetaldehyde reagent M2 and exhibiting 26955 max at 720 nm or 550nm respectively. The Regression analysis of Beers Law plot showed good correlation in a general concentration range of 8-40gml or 4.0-20gml with correlation coefficient r 0.998 for methods M1 and M2 respectively. The proposed methods are validated with respect to accuracy precision linearity and limit of detection. The suggested procedures are successfully applied to the determination of the drug in pharmaceutical preparation with high percentage of recovery good accuracy and precision. The results of analysis have been validated statistically by repeatability and recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of almotriptan in tablet form without the interference of excipients.
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