To Study Synthesis and Antimicrobial Activity of Bidentate Schiff’s Base Ligand Derived from 2- Benzoylpyridine Thiosemicarbazide and Their Ni (II) Complexes

The complexes of nickel (II) derived from 2-benzoylpyridine and thiosemicarbazone ligand having general composition [Ni(L)2X2] (X= NO3 - , Cland OAc- ,½SO4 2- .) have been synthesised. The complexes and ligand under study are characterised by elemental analysis, IR spectroscopy, UV-Vis spectroscopy, mass spectra, conductivity measurement, magnetic susceptibility, EPR spectral studies and NMR Spectroscopy. IR spectral study indicates that ligands behaves as bidentate and coordinated to metal ion through nitrogen and sulphur donor atoms. The molar conductance was measured by using DMSO as solvent. The lower value of molar conductance suggests that the complexes are non electrolytic in nature. The value of magnetic susceptibility indicates that complexes are of low spin type. On the basis of above spectral studies an octahedral geometry may be proposed for all the complexes. The complexes under study were screened for antifungal (i.e., Candida krusei and Candida parapsilosis) and antibacterial (i.e., Escherichia coli and Staphylococcus) activities. The synthesized ligand was bidentate and their complexes were found more active toward antimicrobial activity than ligands.