Efficacy and Safety of Subcutaneous Fat Reduction by Cryoadipolysis

Exuberant fat deposits represent one of the greatest aesthetic concerns of modern society. Furthermore, an excessive accumulation of subcutaneous adipose tissue represents a health problem that can substantially increase the risk of cardiovascular disease, diabetes or cancer. Since the most effective surgical methods to reduce fat deposit, like abdominoplasty or liposuction, imply significant risks associated with general anesthetic and long post-surgical recovery time among other issues, a non-invasive technique represents an appealing alternative to circumvent possible risks. One of non-invasive method to reduce adipose foci is cryoadipolysis. It is a procedure that results in elimination of adipocytes by induction of cell apoptosis after considerable temperature decrease. Cooltech® is one of the leading cryoadipolysis platforms worldwide. Here, we address the mechanisms of action and efficacy of cryoadipolysis, as well as the temperature limits of different non-adipose tissues (skin, nerves, muscles and blood vessels) to address the safety of Cooltech® platform. The detailed revision of bibliographic data is supplemented with experimental and theoretical studies to corroborate the safety of this innovative cryoadipolytic platform.