Formulation, Optimization and Evaluation of Mouth Dissolving Tablet of Zidovudine?

The aim of the present study was to formulate and evaluate the mouth dissolving tablets of Zidovudine. Drug delivery systems are becoming more complex as pharmaceutical scientist acquires better understanding of the physiochemical & biochemical parameters pertinent to their performance, over the last decade. The demand of mouth dissolving tablet has been growing mainly for geriatric and pediatric patients, because of swallowing problem, the characteristics of mouth dissolving tablet for potential emergency treatment. The super disintegrants used in this study was sodium starch glycolate and croscarmellose sodium. The tablets were evaluated for weight variation, hardness, wetting time, friability, water absorption ratio and disintegration time and dissolution study. The tablets were prepared by direct compression method.