RADIATION THERAPY IN MANAGEMENT OF ENDOMETRIAL CARCINOMA: THE RESULTS OF A SINGLE INSTITUTION

Purpose: We report the results of retrospective analysis of 50 cases of endometrial carcinoma treated by radiation therapy at the National Institute of Oncology of Rabat in Morocco. Materials and Methods: Between January 2011 and December 2012, all patients who has benefited from radiation therapy were retrieved. All patients were treated by conformational 3D radiotherapy. We analyzed clinical, histological characteristics, and treatment outcomes. Results: Median age of patients was 58 years. Main symptoms were metrorrhagia in 100% of cases, pelvic pain in 42 % of cases and vaginal discharge in 28%. The FIGO stages were respectively: IA 20 %, IB in 56%, II in 12%, IIIA in 4%, and IIIB in 2% and IIIC in 6 %. Histological grade was 1 in 30%, 2 in 48% and 3 in 22%. All patients underwent surgery. Adjuvant radiation therapy was delivered at a mean dose of 47 Gy (45-50, 4Gy). All patients were treated by conformational 3D radiotherapy. HDR brachytherapy was delivered in 65% of patients at a dose of 10 Gy (2x5Gy). The mean of total treatment duration was 50 days. The overall 5-year survival rate for our study was 90,1 %, and the overall local control rate was 69,6 %. Conclusions: The results of our study confirm that radiation therapy is a good option for treatment of endometrial carcinoma, and it is associated to good outcomes.