SYNTHESIS, CONVERSION AND ANTIMICROBIAL ACTIVITY OF DERIVATIVES OF 2-HYDROXY-1-HALOIDPHENOXYETHERS OF NONANOL-2

Reactivity of hydroxyl group in 1-haloid-phenoxy-2-hydroxynonanes to nucleophilic substitution with acetoxymethylchloride was studied. It was found that regardless of the nature of haloids and their position in aryloxy radical the yields of acetoxymethyl ethers makes nearly 70% that proves high reactivity of hydroxyl group. Indeed, during the reaction with isocyanates phenoxynonanol-2 forms urethanes with yield 69–70%. Initial synthon was prepared by the reaction of 1-bromine-nonanol-2 with substituted phenols. Study of synthesized polyethers and urethanes as antimicrobial additives to lubricating oils gave positive results. It was determined that urethanes exhibit stronger antimicrobial effect than polyethers