An Insilico Methodology for Predicting Novel Micro RNAs with Therapeutic Significance

Micro RNA is a small nucleotide sequence of non coding RNA molecules with a sequence length of 22-24 nucleotides found in plants, virus, animals and humans which help in the process of transcriptional and post transcriptional repression of gene expression [1].Majority of miRNA are intragenic [2].Micro RNAs are initially transcribed as part of an RNA stem-loop that in turn forms part of a several hundred nucleotides long miRNA precursor miRNA (pri-miRNA) [3]. Mature miRNA is a part of an RNA-induced silencing complex (RISC) which contains Dicer and many associated proteins [4].Since miRNA is