Gene silencing by double stranded Ribonucleic acid (RNA)
Journal: World Journal of Biology and Biotechnology (Vol.5, No. 1)Publication Date: 2020-04-15
Authors : Hafiz Ghulam Muhu-Din Ahmed Amna . Shadab Shaukat Iqra Kousar Maria Rafiq Maria Ilyas Aziz Ullah Khuda Buksh;
Page : 41-44
Keywords : RNA; gene; silencing; pathway and plant;
Abstract
Ribonucleic acid (RNA) silencing, RNA interference (RNAi) or post-transcriptional gene silencing takes place in a variety of eukaryotes and it was discovered firstly in the plants. The RNA silencing process is activated by a trigger from dsRNA predecessor. A very important step in the silencing pathways the conversion of dsRNA into small duplexes of RNA of the representative length and arrangement. Then these small dsRNA monitor RNA silencing by different mechanisms. Post transcriptional gene silencing mechanisms were initially identified as an anti-viral process that give protection to the organisms from the viruses or which inhibit the unsystematic incorporation of transposable components. The basic aim of this review article is to study the mechanism of gene silencing by dsRNA and the roles of certain proteins in cellular post transcriptional RNA silencing machinery and finally we also discuss the RNA silencing as an anti-viral defense mechanism in the plants.
Other Latest Articles
- Role of boric acid on economic seed production of alfalfa under climatic conditions of Sargodha
- Food Poisoning: causes, precautions, diagnosis and treatment: A brief review
- Occurrence of Jellyfish Crambionella orsini (Vanhoffen, 1888) (Cnidaria: Scyphozoa) along the coast of Pakistan
- Prediction of live body weights in dromedary camels (Camelus dromedarius) from morphometric body measurements
- Effect of silicon and gibberellic acid on growth and flowering of gladiolus
Last modified: 2020-05-07 18:56:22