Application and Hazards of Nanotechnology in Drug Delivery - A Review
Journal: AlQalam Journal of Medical and Applied Sciences (Vol.1, No. 1)Publication Date: 2017-01-24
Authors : Gerish E Mansour L Dardour A Al-Fallani E Saleh S Al-Tajoury A Abuderhiba KH Abu Senina A;
Page : 77-88
Keywords : Drug Delivery; Nanoparicles; Toxicology; Pharmaceuticals;
Abstract
General concept: Nanotechnology is a revolutionary field of micro manufacturing involving physical and chemical changes to produce nano-sized materials. The word “nano” is a Latin word meaning “dwarf”. Mathematically a nanometer is equal to one thousand millionth of a meter. Although, the initial properties of nanomaterials studied were for its physical, mechanical, electrical, magnetic, chemical and biological applications, recently, attention has been geared towards its pharmaceutical application, especially in the area of drug delivery. Over the last decades, different types of nanoparticles have been developed based on various components, including carbon, silica oxides, metal oxides, nanocrystals, lipids, polymers, dendrimers, and quantum dots, together with increasing variety of newly developed materials. These nanomaterials are capable to provide a high degree of biocompatibility before and after conjugation to biomolecules for specific function so as to translate into nanomedicines and clinical practice. Nanomaterials provide for a favorable blood half-life and physiologic behavior with minimal off-target effects, high specificity towards the target site, effective clearance from the human organism, and minimal or no toxicity to healthy tissues in living organisms. In addition, the nanosize also allows for access into the cell and various cellular compartments including the nucleus. Nanotechnology definitely promises to serve as drug delivery carrier of choice for the more challenging conventional drugs used for the treatment and management of chronic diseases such as cancer, asthma, hypertension, HIV and diabetes. This review provides an overview on the currently used systems of nanotechnology in drug delivery, applications and hazards of nanotechnology in pharmaceuticals release. Conclusion: Although for pharmaceutical use the current requirements seem to be adequate to detect most of the adverse effects of nanoparticle formulations, it can not be expected that all aspects of nanoparticle toxicology will be detected. So, probably additional more specific testing would be required.
Other Latest Articles
- Molecular Detection of Chicken Infectious Anaemia Virus from Backyard Chickens in Libya
- Assessment of Biosafety and Biosecurity Aspects in Diagnostic Clinical Laboratories in Tripoli, Libya
- Isoflurane versus Desflurane for Anaesthesia in Surgical Operation: A Comparison of Maintenance and Hemodynamic Profile
- Study of Risk Factors for Toxoplasma gondii infection in Tripoli
- Microbiological Quality and Detection of the Genes Stx1 and Stx2 in Fresh Sausage Marketed in Tripoli, Libya
Last modified: 2020-05-16 23:04:59