TASTE MASKING OF OXYBUTYNIN CHLORIDE USING LIPID EXCIPIENTS AND FORMULATION AS ORODISPERSIBLE TABLETS FOR GERIATRIC POPULATION
Journal: Indian Drugs (Vol.50, No. 10)Publication Date: 2013-10-28
Authors : Prakash V. Keshri L. Sharma V.; Pathak K.;
Page : 39-46
Keywords : vijay_ceutics07@yahoo.co.in;
Abstract
The aim of the present study was to mask the bitter taste of oxybutynin chloride by lipid excipients and todevelop its fast disintegrating tablet. For this purpose, a blend of two lipids, glyceryl behenate and glycerylpalmitostearate was utilized for taste masking by solvent evaporation method. The evaporation of solventwas accomplished by freeze drying and taste masked granules were characterized for their micromeriticand rheological properties. The state of dispersion was analyzed by SEM and DSC. Orodispersibletablets were then formulated (F1- F6) using Polyplasdone XL as extragranular superdisintegrant andevaluated for hardness, disintegration time, in vitro dissolution time and in vivo disintegration time. Resultsindicated that the formulation F6 exhibited minimum in vivo disintegration time of 8 sec with effectivetaste masking. In vitro release analysis indicated %DE10 and %DE25 of 51.48 and 76.53 respectively.Conclusively, taste masked orodispersible formulation of oxybutynin chloride was developed that couldbe beneficial for geriatric population.
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