EFFECT OF POLYHERBAL FORMULATION RUMALAYA FORTE ON ADJUVANT INDUCED ARTHRITIS IN RATS

Anti-arthritic activity of Rumalaya Forte (RF), a polyherbal formulation was evaluated by in vivo Complete Freunds Adjuvant induced arthritis animal model in rats. RF 80 mg/kg and 160 mg/kg offered significant anti-inflammatory activity by inhibiting primary lesion on day 5, RF 160 mg/kg body weight has profound anti-arthritic activity than low dose RF 80 mg/kg with significant reduction in mononuclear infiltration, pannus formation and bone erosion in as observed in histological studies. Dexamethasone as standard exhibited a greater reduction in body weight compared to other groups while arthritic score was comparably significant with that of RF 160 mg/kg concentration.