EFFECT OF POLYHERBAL FORMULATION RUMALAYA FORTE ON ADJUVANT INDUCED ARTHRITIS IN RATS
Journal: Indian Drugs (Vol.49, No. 10)Publication Date: 2012-10-28
Authors : Subash K. R. Cheriyan B. V. Parvathavarthini S. Bhaarati G. M.; Venugopal V.;
Page : 18-24
Keywords : *E-mail: subbu2207@yahoo.com;
Abstract
Anti-arthritic activity of Rumalaya Forte (RF), a polyherbal formulation was evaluated by in vivo Complete Freunds Adjuvant induced arthritis animal model in rats. RF 80 mg/kg and 160 mg/kg offered significant anti-inflammatory activity by inhibiting primary lesion on day 5, RF 160 mg/kg body weight has profound anti-arthritic activity than low dose RF 80 mg/kg with significant reduction in mononuclear infiltration, pannus formation and bone erosion in as observed in histological studies. Dexamethasone as standard exhibited a greater reduction in body weight compared to other groups while arthritic score was comparably significant with that of RF 160 mg/kg concentration.
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