EVALUATION OF WOUND HEALING ACTIVITY OF SILVER SULFADIAZINE EMULGEL (1%) IN THE RAT BURN WOUND MODEL AND ITS SKIN IRRITATION STUDY
Journal: Indian Drugs (Vol.49, No. 11)Publication Date: 2012-11-28
Authors : Patil P. J. Chaudhari S. P.; Ghodekar S. V.;
Page : 40-43
Keywords : *E-mail: praviny2k2001@yahoo.com;
- EVALUATION OF WOUND HEALING ACTIVITY OF SILVER SULFADIAZINE EMULGEL (1%) IN THE RAT BURN WOUND MODEL AND ITS SKIN IRRITATION STUDY
- A COMPARATIVE STUDY OF THE EFFICACY OF NANOCRYSTALLINE SILVER WITH COLLAGEN BASE CREAM AND 1% SILVER SULFADIAZINE (SSD) CREAM ON THE HEALING OF BURN WOUND
- Acute and Chronic Wound Fluid Inversely Influence Wound Healing in an in-Vitro 3D Wound Model
- Evaluation of the wound healing effect of Jasminum grandiflorum by wound contraction studies and wound breaking strength
- Formulation and Evaluation of Herbal Skin Cream for Wound Healing Activity
Abstract
The study provides a scientific evaluation of the biological and therapeutic properties of new topical formulation of silver sulfadiazine emulgel (1%) as an alternative for the treatment of burn wounds. The solid dispersion was prepared with poloxomer 407 by melt method and is used for emulgel formulation. The prepared silver sulfadiazine emulgel (1%) was compared with marketed silver sulfadiazine creamon healing of burn wounds in rats. Burned area evaluations on the 4th, 8th, 12th and 16th days showed statistically significant better burn wound healing in silver sulfadiazine emulgel (1%) as compared to marketed silver sulfadiazine (1%) group. Moreover, it showed no irritation when tested in rabbit skin irritation test. In conclusion, application of silver sulfadiazine emulgel may be more effective in healing burn related skin wounds in the rat model.
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