ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF IXORA COCCINEA FLOWER

The present study was an endeavor to evaluate anti-inflammatory and analgesic activity of methanolic extract of Ixora coccinea flowers (ICF-ME). The in vivo anti-inflammatory was evaluated in rats by using carageenan-induced paw edema, as an acute anti-inflammatory model. Quantitative estimation of total polyphenolic content of I. coccinea flowers was estimated by ICF-ME (100 mg/kg) significantly decreased paw volume, after oral administration of ICF-ME in carrageenan injection. ICF-ME also exhibit significant analgesic activity. The response of licking or jumping latency was recorded in seconds by using hotplate method. Presence of phytochemical like flavonoids, glycosides, and tannins in the ICF-ME might contribute to the observed analgesic and anti-inflammatory activity.