SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND DESLORATADINE IN BULK AND IN TABLET FORMULATION BY UV-SPECTOPHOTOMETRY
Journal: Indian Drugs (Vol.50, No. 3)Publication Date: 2013-03-25
Authors : Jain R. R. Patil P. O.; Bari S. B.;
Page : 30-35
Keywords : *E-mail: rxpatilpravin@yahoo.co.in;
Abstract
Novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of montelukast sodium (MONTE) and desloratadine (DES). The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths 285.6 nm and 245 nm, the λmax values of MONTE and DES, respectively. Beer's law was obeyed in the concentration range of 4-24 µg/mL and 2– 12 µg/mL for MONTE and DES, respectively. The method was validated for accuracy, precision and recovery studies. The developed method was precise, reproducible, selective, specific and accurate for quantitative estimation of MONTE and DES, in combination. The wide linearity range, sensitivity, accuracy, and simple procedure demonstrated the method to be appropriate for routine analysis and quality control assays of their tablets. The method was validated according to the ICH guidelines.
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