PULSATILE DRUG DELIVERY A PROGRAMMED POLYMERIC DEVICE

Pulsatile Drug Delivery Systems are gaining a lot of interest as they deliver the drug at the right place, at the right time and in the right amount, thus providing spatial, temporal and smart delivery and increasing patient compliance. The use of pulsatile release of the drugs is desirable where constant drug release is not desired. These systems are designed according to the circadian rhythm of the body. According to Latin literature circa means about and Diem means day. This could be advantageous for many drugs or therapies including asthma, peptic ulcer & arthritis etc. To correlate with our biological needs, “precisely timed drug delivery,” which could be accomplished with “programmable dosage forms,” is desirable. Precisely timed drug delivery may maximize therapeutic efficacy, minimize dose frequency, and may reduce toxicity. This paper outlines the concepts that have been proposed to release drugs in a pulsed manner from pharmaceutical device.