SYNTHESIS OF ALKYL DERIVATIVES OF PLUMBAGIN

A series of alkyl derivatives of plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone), analogous toVitamin K, have been synthesized. Plumbagin reacts with carboxylic acid in presence of silver nitrateand ammonium peroxydisulphate to form its alkyl derivatives. The compounds synthesized werecharacterized by MS, IR, 1H and 13C-NMR Spectroscopy. The derivatives prepared may find applicationas antithrombotic agents and may facilitate designing of similar newer analogues.