EVALUATION OF ANTIARTHRITIC ACTIVITY OF YOGRAJ GUGGUL FORMULATION IN FREUNDS ADJUVANT INDUCED POLY-ARTHRITIC RAT MODEL

The paper discusses evaluation of antiarthritic activity of Yograj guggul formulation in freund's adjuvant induced poly-arthritis rat model. The findings demonstrate that the treatment with Yograj guggul formulation (200, 400 mg/kg/day) for 14 days produced a significant anti-arthritic activity (decreased arthritic index), inhibited connective tissue metabolism (reduced hydroxyproline and hexosamine content of edematous tissue) and caused haematological alterations (WBC, RBC, ESR and differential cell count) occur during Freund's adjuvant induced polyarthritis in rats. The antiarthritic effect of Yograj guggul formulation at 400 mg/kg was comparable to that of reference drug, diclofenac sodium (10 mg/kg). The antiarthritic activity observed in the present study may be attributed to the various herbs present in the formulation. It is proposed that, the Yograj guggul formulation elicited antiarthritic activity largely due to the prevention of connective tissue breakdown, decreased capillary permeability and improvement of immune system.