ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

Synthesis And Optimization of Streptomycin Loaded Chitosan-Alginate Nanoparticles

Journal: International Journal of Scientific & Technology Research (Vol.1, No. 10)

Publication Date:

Authors : ; ; ; ;

Page : 31-34

Keywords : Keywords Streptomycin; Chitosan; Sodium alginate; nanoformulations; calcium chloride; ionotropic pregelation;

Source : Downloadexternal Find it from : Google Scholarexternal


Abstract- Nanoformulation consisting of Streptomycin loaded chitosan-alginate nanoparticles were prepared using ionotropic-pregelation method and optimization was done in terms of polymer concentration crosslinker concentration and stirring time. The optimal parameters were found to be Chitosan 0.75mgml calcium chloride 1 wv and stirring time 90 min. Polymer chitosan and sodium-alginate and crosslinker calcium-chloride at these concentrations had significant synergistic effect on particle size and encapsulation efficiency. Increase in polymer and crosslinker concentration resulted in an increase in particle size. Encapsulation efficiency first showed an increase followed by a decrease on increasing the polymer concentration whereas it increased with an increase in cross linker concentration. The nanoformulation so formed showed particle size 328.4 nm 26 drug encapsulation 93.32.

Last modified: 2013-04-13 21:50:05