REVERSAL OF HYPERMETHYLATION AND REACTIVATION OF TUMOR SUPPRESSOR GENES DUE TO NATURAL COMPOUNDS IN BREAST CANCER CELLS

Breast oncogenesis is a multistage process that involves epigenetic and genetic changes. Epigenetics is outlined as reversible changes in gene expression, with no alteration in gene sequence. DNA methylation, histone modification, and nucleosome transformation are the foremost epigenetic changes that may get dysregulated in breast cancer. Epigenetic silencing of tumor suppressor genes (TSGs) is reversed by varied molecules as well as natural compounds like polyphenols which will act as a hypermethylation agent. Nowadays, much of the research is going in the direction of natural and dietary compounds and attempting to search out novel and extra effective medical aid for the breast cancer patients. In this literature, few vital natural chemical compounds effective against the breast oncogenesis with their mode of actions are discussed. Such chemicals act as an analytical and prognostic tool in breast cancer due to their role in epigenetic regulation.