Adipose stem cells in the clinic

Adipose derived stem cell (ADSC) is the most popular mesenchymal stem cells (MSCs) used in the clinic in recent years. ADSC transplantation has some advantages compared to others from bone marrow, umbilical cord blood... ADSCs produced important growth factors for wound healing, modulate the immune system, decrease inflammation, and home in on injured tissues. Particularly, ADSC extraction from adipose tissue is a simple procedure with minimum invasion in the patients. Therefore, ADSCs were used in the treatment of many diseases and clinical trials since 2000s. To date, ADSC transplantation was approved in some countries to treat medical complications such graft versus host disease, osteoarthritis... This review is an overview of applications and future challenges of ADSC in clinic.