NEW VALIDATED RP-HPLC METHOD FOR THE DETERMINATION OF RIZATRIPTAN BENZOATE IN BULK AND PHARMACEUTICAL DOSAGE FORM
Journal: Indian Drugs (Vol.51, No. 12)Publication Date: 2014-12-28
Authors : T. Vishalakhi Kumar S. K K Sujana; Rani. P.;
Page : 32-36
Keywords : sathishkonidala@gmail.com;
Abstract
A simple validated RP HPLC method for the estimation of rizatriptan benzoate in pharmaceutical dosage form and bulk was developed for routine analysis. This method was developed by selecting Agilent TC C18 (250 x 4.6 mm, 5 μ) column as stationary phase and acrylonibrile:water (45:55), pH adjusted to 3, as mobile phase. Flow rate of mobile phase was maintained at 4: 1 mL/min at ambient temperature throughout the experiment. Quantification was achieved with ultraviolet (DAD) detection at 220 nm. The retention time obtained for rizatriptan was 2.8 min. The detector response was linear in the concentration range of 2-25μg/mL. This method was validated and shown to be specific, sensitive, precise, linear, accurate, rugged and robust. Hence, this method can be applied for routine quality control of rizatriptan benzoate in dosage forms as well as in bulk drug.
Other Latest Articles
- VISIBLE SPECTROPHOTOMETRIC METHODS FOR ESTIMATION OF LANSOPRAZOLE IN PHARMACEUTICAL FORMULATION
- A NEW BIOANALYTICAL METHOD DEVELOPMENT & VALIDATION FOR SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND SITAGLIPTIN PHOSPHATE MONOHYDRATE IN HUMAN PLASMA BY USING RP-HPLC
- DESIGN, DEVELOPMENT AND CHARACTERIZATION OF SIMVASTATIN LOADED TRANSFERSOMAL GEL FOR TRANSDERMAL DRUG DELIVERY
- FORMULATION AND EVALUATION OF CURCUMIN LOADED NANOCRYSTAL FOR DIABETES THERAPY
- DEVELOPMENT AND VALIDATION OF RP-UPLC METHOD USING EXPERIMENTAL DESIGN APPROACH FOR SIMULTANEOUS ESTIMATION OF CANDESARTAN CILEXETIL AND CHLORTHALIDONE
Last modified: 2020-06-15 20:04:55