Formulation and Evaluation of Ganciclovir Novel Buccoadhesive Tablets with Different Polymers

The main objective of purpose study is to formulate buccal drug delivery system of Ganciclovir by using different types of mucoadhesive polymers which may increase the intimacy and duration of contact between drug- containing polymer and a mucous surface which will increase the residence time of drug in the body and finally increase the bioavailability of this highly water soluble drug. The direct drug absorption and decrease in excretion rate will also increase the bioavailability. Buccal cavity was found to be the most convenient and easily accessible site for the delivery of therapeutic agents for both local and systemic delivery as retentive dosage form.