Gemifloxacin with Different Essential Metals, In Vitro Interaction and Investigation of Antimicrobial Activity

— The research work comprises of interaction studies of Gemifloxacin with essential metals and investigation of antimicrobial activity of Gemifloxacin. Gemifloxacin is included among the fluoroquinolones drug class which is active against a wide range of gram positive and negative bacteria. Since the presence of compelling ligand may affect the bioavailability of a metal in the blood or tissues, therefore in order to study the probable interaction of Gemifloxacin with essential and trace elements present in the body. Gemifloxacin has been interacted with Fe – (Ferrous), Zn- (Zinc) metal salts in vitro. All the reaction conditions were simulated to natural environment. Also the antimicrobial activity of the drug and the complexes were determined. There is a effect of PH on drug metal complexation. It has observed that Gemifloxacin interacts with metal on a PH 7.4, the stability constant of these complexes were determined in order to evaluate their possible in vivo implications. In order to investigate the number of metal ions involved in the complexion with Gemifloxacin complexes w