Hypolipidemic Effect of Ethanolic Seeds Extract of Baccaurea ramiflora in Wister Albino Rats

Baccaurea ramiflora is an evergreen medicinal plant which is also known as Burmese grape. In rural and remote areas in Bangladesh as well as other south Asian countries, it is commonly used as a rich nutritional source of vitamin C. Hyperlipidemia is a condition which is characterized by elevated levels of serum lipid profile which is a major risk factor for cardiovascular diseases and diabetes. The aim of the current study was to evaluate the therapeutic effect of oral administration of ethanolic seed extract of B. ramiflora on serum lipid profile in Wister albino rats. Effect of alcoholic seed extract of B. ramiflora on lipid profle was conducted. Thirty albino rats were divided into six groups of 5 rats each. Among thirty rats, twenty five rats were given high cholesterol diet for six weeks to increase body weight. Group I was normal control, group II hyperlipidemic control, groups III, IV, and V were hyperlipidemic rats orally administered with 150 mg/kg, 250 mg/kg, and 500 mg/kg of ethanolic seed extract of B. ramiflora, respectively, for 4 weeks, and group VI were hyperlipidemic rats orally administered with 10 mg/kg of Rosuvastatin for 4 weeks. Significant (P < 0.05) increase in the serum Total Cholesterol, Triglycerides, and LDL-cholesterol were observed in groups II, III, IV, V, and VI when compared with that of the group I. Significant (P < 0.05) decrease in mean serum Triglyceride, total cholesterol and LDL-cholesterol levels were found in rats orally administered with 500 mg/kg of ethanolic seed extract of B. ramiflora and those orally administered with 10 mg/kg of rosuvastatin when compared with test control group. From the study, it could be suggested that ethanolic seed extract of B. ramiflora at 500 mg/kg can be used as antihyperlipidemic agent against dietary-induced hyperlipidemia.