AROMATIC HYDROCARBONS OF Arthropodae SPECIES: MECHANISMS OF ACTION ON BIOLOGICAL MEMBRANES AND PERSPECTIVES OF BIOMEDICAL APPLICATION

The work was aimed to summarize the results describing the mechanisms of interaction of some aromatic hydrocarbons, isolated from Arthropodae, with biological membranes. Neurophysiological properties of the substances obtained from spider venoms, derivatives of phenol and indole with polyamine substituents, were studied by the method of transmembrane electrical currents registration in voltage clamp mode. Their influence was revealed as a result of chemo sensitive ionic currents characteristics changes due to the action of these substances on the membranes of rat hippocampal neurons. All of the studied substances were antagonists of glutamate channel-receptor complexes. Their blocking activity characteristics were examined as follows: caused reversible and irreversible blocking effects, the effects dependence on membrane holding potential, difference of their action on activated and inactivated receptors, kinetics of blocking actions, type of antagonism. Antagonists amphiphilic properties and the role of aromatic groups and polyamine substituents during interaction with the membranes were analyzed. The results of such analysis were accepted as a basis for development of physical model of artificial memory device. Principles of its work were explained as well. The results regarding the influence mechanisms of the studied substances on biological membranes were summarized. Some characteristics and functioning peculiarities of the suggested elements of storage devices were discussed. The properties of the proposed substances-analogues meet a number of requirements for the elements of such nano-devices.