Analysis of the Use of Antioxidant (Vitamin C and E) on the Calculation of Blood Eosinophil on the White Missing White Walking Swiss Webster Character Exposed to Peat Smoke

He peatlands fire produce particles and gasses component such as sulfur dioxide (SO2 ), carbon monoxide (CO), nytrogen oxide (Nox) and ozone (O3 ) that caused health problems. The expose of the smoke will activate CD4+ and mast cell on respiratory system. The CD4+ will differentiated into Th2, while in the differentiated proses, it will produce IL-4 and IL-5. Th2 that merge with IL-5 could activate and increase the eosinophil production. Eosinophil is an inflammation cell that have a main role in chronic inflammation proses of respiratory system. One effort to prevent the effects of smoke is by consuming antioxidants. This study aims to determine the analysis of antioxidant consumption to count the number of blood eosinophils in white male Swiss Webster strains exposed to peat smoke. This research is laboratory experimental research and the design used is Post Test Only Control Group Design. The research was carried out at the FK Unsri animal house for 30 days in July 2019. The samples were 33 male white Swiss Webster mice divided into 2 treatment groups and 1 control group. Data were analyzed by the Kruskall-Wallis and Mann-Whitney tests which were processed using SPSS version 22 for windows. Research results prove that exposure to peat smoke increases eosinophil levels. Consumption of antioxidants can reduce the count of blood eosinophils in white male Swiss Webster strains exposed to peat smoke (p Value = 0.037