Ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia in complex cardiac surgery

Pseudothrombocytopenia is an unusual hematological disorder, which develops in response to ethylenediaminetetraacetic acid-dependent anti-platelet autoantibodies in blood, leading to platelet clumping. It is only an in vitro phenomenon, which presents with low platelet counts in routine hematology analysis. The definitive diagnosis should be established to avoid a delay in surgery and unnecessary blood transfusion in patients undergoing cardiovascular surgery. Herein, we present a 51-year-old female case with ethylenediaminetetraacetic acid-dependent pseudothrombocytopenia, who underwent a successful aortic root and valve surgery, and discuss perioperative management of this rare disorder.