Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis
Journal: Molecular and Cellular Biomedical Sciences (Vol.3, No. 1)Publication Date: 2019-03-01
Authors : Lestariningsih Lestaringsih Wiguno Projosudjadi Mochamad Sya'bani Suharyo Hadisaputro;
Page : 48-53
Keywords : hemodialysis; atherosclerosis; IMT; IL-6; hs-CRP; Oxidized-LDL;
- Correlation between the Inflammation Factors and Intima-Media Thickness in Patients with End-Stage Renal Disease (ESRD) on Regular Hemodialysis
- THE CORRELATION AMONG CAREER THOUGHTS, DIALYSIS VARIABLES AND DEMOGRAPHIC CHARACTERISTICS OF BAHAMIAN PERSONS DIAGNOSED WITH END STAGE RENAL DISEASE (ESRD) ON HEMODIALYSIS
- Epidemiological Profile of Patients of End Stage Renal Disease (ESRD) for Hemodialysis (HD) at Tertiary Care Rural Hospital of Subhimayalian Region of India
- Efficacy of Ombitasvir/Paritaprevir/Ritonavir plus Ribavirin in Treatment of Chronic Hepatitis C Patients with End Stage Renal Disease on Regular Hemodialysis
- A CROSS-SECTIONAL RESEARCH ON RESTLESS LEGS SYNDROME (RLS) IN THE PATIENTS OF END STAGE RENAL DISEASE (ESRD) AND IT’S ASSOCIATED RISK FACTORS IN THE LIGHT OF REVISED INTERNATIONAL RLS CRITERIA (2012)
Abstract
Background: Several emerging problems of regular hemodialysis (HD) including cardiovascular complication or atherosclerosis formation caused by chronic inflammation. High sensitive C-reactive protein (hs-CRP) and intima-media thickness (IMT) of the carotid artery can be applied as atherosclerosis progressivity marker. This study was designed to investigate the relationship between some inflammatory factors, including hs-CRP, interleukin (IL)-6, oxidized-low-density lipoproteins (LDL), with IMT among end-stage renal disease (ESRD) patients. This was the first study in Indonesian population. Materials and Methods: This cross-sectional study was performed on ESRD patients who performed regular HD at Hemodialysis Unit of Dr. Kariadi Hospital and Telogorejo Hospital Semarang between October 2009 and April 2010. This was a preliminary report for the cohort study. Results: Seventy-eight HD subjects were enrolled in this study, with mean age of 49.8 years old. Mean HD duration was 25.5±32.16 months. The mean carotid artery wall thickness was 0.64±0.149 mm. IL-6, hs-CRP, and ox-LDL level were higher in IMT group ≥0.5 mm than IMT group <0.5 mm. There was a significant correlation between hs-CRP (prevalence ratio (PR)=1.3; 95% confidence interval (CI)=1.02-1.7; p-value=0.01) as well as IL-6 (PR=1.5; 95% CI=1.1 -2.0; p-value<0.001) and IMT wall thickness. The oxidized-LDL level was not a significant factor to be associated with IMT. The cut-off value for hs-CRP and IL-6 to predict IMT progressivity was 2.8 mg/L and 2.88 mg/L, respectively. Conclusion: There was a significant correlation between IL-6 and hs-CRP levels and IMT. There was not significant correlation between oxidized LDL and IMT.
Other Latest Articles
- Correlation Between Pyridoxal 5’-Phospate Level And Valproic Acid In Epilepsy Children
- Cytotoxic Activity of Methoxy-4’amino Chalcone Derivatives Against Leukemia Cell Lines
- The Effect of Human Platelet-Rich Plasma and L-Ascorbic Acid on Morphology, Proliferation, and Chondrogenesis Ability towards Human Adipose-Derived Stem Cells
- Soymilk Formula Increases Estrogen and Reduces Testosterone Level in Male Infant White Wistar Rats
- Microbial Patterns and Antimicrobial Susceptibility on Pediatric Patients with Pressure Ulcers
Last modified: 2020-07-02 12:10:25