Nanohybrid based on layered zinc hydroxide with salicylic acid drug: Investigation of the structure and controlled release properties
Journal: Journal of Medicinal and Chemical Sciences (Vol.3, No. 3)Publication Date: 2020-07-01
Authors : Hafezeh Nabipour; Yuan Hu;
Page : 235-244
Keywords : Salicylic Acid; Layered zinc hydroxide; Nanohybrid; structure; Controlled release;
Abstract
Recently, nanoparticles have attracted much attention owing to their potential in biomedical applications, such as drug delivery systems, sustained release and controlled release. Various nanocarriers have been employed to ameliorate the efficacy and cytotoxicity of drugs, reducing their side effects through changing their pharmacokinetic properties. A simple and well-known model of pharmaceutical carriers is the layered zinc hydroxide (LZH) compound. In the present research, salicylic acid (Sal)-loaded LZH was synthesized using the ion-exchange method. The resulted nanohybrid (Sal-LZH) was characterized using the PXRD, FT-IR spectroscopy, STA analysis, BET, and SEM. Sal anions were intercalated into the interlayer gallery space of LZH, leading to different drug releases at pH 4.8 and 7.4. It was found that, the release of Sal anions from the synthetic nanohybrid occurred in a controlled manner, and the resulting material is suitable for use as a controlled-release formulation for various kinds of anti-inflammatory agent.
Other Latest Articles
- Solar light photo-catalyzed condensation of aldones with 4-phenylthiosemicarbazide, a green chemistry approach
- Novel unsymmetric diimines: Synthesis and biological evaluation against pathogenic microorganisms
- Chemical screening for codeine and tramadol in urine of anonymous students attending university sick bays
- Adsorption of melphalan anticancer drug on the surface of boron nitride cage (B12N12): A comprehensive DFT study
- Textural Profile Analysis of Burfi Prepared in Three Stage Scraped Surface Heat Exchanger
Last modified: 2020-07-06 23:23:36