AN ASSESSMENT OF THE INTERACTION BETWEEN INSECT BRAIN PROTEIN AND NON-STRUCTURAL PROTEIN OF CORONAVIRUS USING IN-SILICO ANALYSESJournal: International Journal of Advanced Research (Vol.8, No. 5)
Publication Date: 2020-05-21
Authors : Siddharth Sagar Jayaprada Rao Chunduri; Vyomesh Javle;
Page : 436-452
Keywords : Ribovirus Antibacterial Protein Molecular Docking Non-Structural Protein;
Corona is an avian and mammalian Ribovirus which generally evade host immune mechanism hampering respiratory tract of the host. Structurally it has an envelope of protein enclosing a single-stranded positively coiled RNA genome. Coronavirus uses around 4-5 different classes of protein for its replication in the host cell. Due to the high mutation rate of the viral genome development of a vaccine against corona has been a difficult task. In the current scenario, the world is facing a problem with CoViD-19 as the biggest pandemic. Several combinations of drugs like Hydroxychloroquine, Plaquine, Chloroquine, etc. targeting viral protein have been utilized for controlling viral infection. The possibility of insect brain proteins was checked against the selected non-structural proteins of CoViD-19 that take an active role in the replication of the virus in the host. Molecular docking methodology plays an important role in predicting interaction between the insect proteins with non-structural protein (nsp) of coronavirus. The results predict good bonding affinity with possible interaction as hydrogen bond and salt bridge between antibacterial protein and nsp of CoViD-19 indicating as afuture alternative medications.
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