A STUDY OF ENDOTHELIAL DYSFUNCTION IN PREDIABETICS AS EVIDENCED BY FLOW MEDIATED VASODILATION IN COLOR DOPPLER OF BRACHIAL ARTERY

Endothelial dysfunction is an early event and it precedes atherosclerosis. Does endothelial functional assessment can provide valuable insight into PRE-INTRUSIVE phase of atherosclerosis . Flow mediated dilation is known to depend on ability of endothelium to release nitric oxide in response to shear stress and can be used to estimate reliably endothelial function.PRE-DIABETIC PATIENTS have endothelial dysfunction due to HYPER GLYCAEMIA and INSULIN RESISTANCE. This study was under taken in pre diabetics to know the occurrence of endothelial dysfunction. Endothelial dysfunction was assessed Non - Invasively by Doppler Ultrasound of brachial artery of pre diabetic patients who had impaired Fasting Plasma Glucose. Flow mediated dilatation was calculated as percentage increase in brachial artery diameter in response to increase in brachial artery flow. The importance of unravelling mechanistic link between early insulin resistance and accelerated atherosclerosis is underscored by recent finding even in adolescents mild insulin resistance is associated with increased cardio vascular risk. Decreased nitric oxide bio- availability in endothelium is of particular relevance in pre-diabetics. This study was done with that hypothesis that insulin resistance is a substrate for accelerated atherosclerosis depicted by endothelial dysfunction. The findings in our study are that mild insulin resistance is associated with accelerated endothelial dysfunction.