SYNTHESIS CHARACTERIZATION AND DOCKING STUDY OF HCV NS3/4A PROTEASE INHIBITOR MOLECULES

A sharp rise in the number of hepatitis C patients has been observed worldwide in the last decades. This has attracted the attention of researchers and medical professionals to provide cheap and effective treatment options for the eradication of hepatitis C. The present study describes the synthesis of a number of novel molecules which may be capable of inhibiting progression of the virus. The molecules were synthesized using the general techniques of the peptide bond preparation. Synthesized molecules were characterized by elemental analysis and spectral studies such as Mass, UV/Vis, IR and NMR. Purity of the molecules was determined by HPLC. Molecules with purity more than 98.5 % were selected for further docking studies to determine their interaction with binding site of NS3/4A protease on HCV RNA.