Beneficial Effects of Achillea Millefolium and Aesculum Hippocastanum Extracts on Glutamate Excitotoxicity in the Primary Cultured Neurons

Achillea millefolium and Aesculum hippocastanum extracts are natural products which have antioxidant effects. It is well known that neurotoxicity caused by glutamate excitotoxicity is linked to oxidative stress. In this study we investigated the potential neuroprotective effects of Achillea millefolium and Aesculum hippocastanum extracts against glutamate excitotoxicity in the primary cultured neuron cells. According to our MTT results Achillea millefolium and Aesculum hippocastanum had neuroprotective effects against glutamate excitotoxicity in the cortical neuron cells. Achillea millefolium and Aesculum hippocastanum were showed to inhibit the glutamate induced TOC levels and also showed to increase TAC levels which decreased by glutamate excitotoxicity. We have demonstrated that Achillea millefolium and Aesculum hippocastanum protected against glutamate induced excitotoxicity at different doses in the primary cultured neuron cells via antioxidative pathway.