Modulatory Effects of Vitamin C and E on Cypermethrin-Induced Cardiac and Hepatic Damage in Female Wistar Rats

The rationale behind this study was to determine the possible ameliorating effect of Vitamin C and E on Cypermethrin induced toxicity in heart and liver function of female albino rats. Twenty-eight female albino rats were sorted into four groups of seven rats per groups were used in this study. Group A serves as the control and received distilled water orally. Group B, C and D were administered 25mg/kg body weight cypermethrin orally. Group C and D were treated daily with 40mg/kg body weight vitamin C and 20mg/kg body weight vitamin E respectively by oral administration while group B was left untreated for 14 days. Cypermethrin significantly (P<0.05) induced cardiac and hepatic damage as characterized by elevated levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic bilirubin and decrease in cardiac albumin, globulin, total protein, ALP, LDH and GGT. However, treatment with vitamin C and E significantly ameliorate the adverse effects of Cypermethrin. Histological examination of the cadiac and hepatic tissues correlates with the biochemical results indicating marked distortions in the architecture of heart and liver of rats administered Cypermethrin alone but treatment with vitamin C and E attenuated these alterations. In conclusion, vitamin C and E effectively suppress the toxicity effects of Cypermethrin in heart and liver of rats by scavenging the free radicals and protecting the membrane integrity of the tissues.