Antiviral Activity of Dipyridamole in Experimental Viral Infections in Mice

Single application of the interferon inducer dipyridamole administered intraperitoneally or per os demonstrated a marked antiviral effect in mice with experimentally induced alphavirus infection –Semliki Forest (SFV) virus-caused encephalitis, applied orally in influenza virus A/Puerto Rico/8/34 (H1N1) and B/Lee/40 – respiratory infections, and herpes simplex virus type 1, strains Lennett and Leningrad 2 – encephalitis, and HSV-1 strain Leningrad 2-caused skin infection. In brain and respiratory infections the antiviral activity was manifested via the protection index, a decrease in the cumulative mortality percentage, and by the prolongation of the mean survival time. In the HSV-1 dermatitis suppression of symptomatology was observed.