A Rare Association of Silent Celiac Disease, Acute Hepatitis and Aplastic Anemia: Case Report and Review of Literature
Journal: International Journal of Celiac Disease (Vol.6, No. 2)Publication Date: 2018-08-28
Authors : Amel Tej Imene Akari Raoudha Kbaili Fehmi Ferhi Ibtissem Ghdira Samia Tilouche Kahloul Najoua Jihene Bouguila Lamia Boughamoura;
Page : 58-61
Keywords : celiac disease; hepatitis; aplastic anemia; gluten free diet;
- A Rare Association of Silent Celiac Disease, Acute Hepatitis and Aplastic Anemia: Case Report and Review of Literature
- APLASTIC ANEMIA WITH SUB CONJUNCTIVAL HAEMORRHAGE AND PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA: A RARE CASE REPORT
- A Silent or Hypo-symptomatic Disease Can Erupt: Acute Presentations of Celiac Disease
- An Interesting Case of Aplastic Anemia and Acute Kidney Injury
- A RARE OCCURRENCE OF METASTATIC GASTRIC ADENOCARCINOMA CAUSING ACUTE SPONTANEOUS TUMOR LYSIS SYNDROME AND ACUTE RENAL FAILURE: A CASE REPORT AND REVIEW OF THE LITERATURE
Abstract
Liver abnormalities are common extra-intestinal manifestations of celiac disease (CD). However, aplastic anemia had been rarely described in this disorder. Here, we report an exceptional case suggesting a rare association between asymptomatic CD, acute hepatitis and aplastic anemia: A Nine-year old girl presented with jaundice of 3 weeks duration and hepatosplenomegaly on physical exam. Investigations revealed an acute liver disorder with high serum transaminases levels. Extensive investigations excluded infectious, metabolic and auto immune as cause of acute liver disease. A celiac disease was diagnosed according to the histological exam of small bowel biopsy. A reversal of hepatic disorder was observed within 2 months after the initiation of Gluten free diet. However, the child developed aplastic anemia, which dramatically worsened despite immunosuppressive therapy. The etiological assessment of aplastic anemia was negative suggesting an association with hepatitis and silent celiac disease that could be explained by a common underlying immune pathological mechanism. Therefore, a screening of CD in acute liver disorder and AA should been considered by clinicians.
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